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Article

A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.

The Journal of biological chemistry - 28 May 2010

Griner Erin M, Caino M Cecilia, Sosa Maria Soledad, Colón-González Francheska, Chalmers Michael J, Mischak Harald, Kazanietz Marcelo G

Abstract excerpt

Although the family of chimaerin Rac-GAPs has recently gained significant attention for their involvement in development, cancer, and neuritogenesis, little is known about their molecular regulation. Chimaerins are activated by the lipid second messenger diacylglycerol via their C1 domain upon activation of tyrosine kinase receptors, thereby restricting the magnitude of Rac signaling in a receptor-regulated...

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Identifiers

PMID: 20335173
DOI: 10.1074/jbc.M109.099036
PMCID: PMC2878072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.PMID 20335173Read ↗

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