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Article

Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.

Biochemistry - 1 Sept 2009

Sosa Maria Soledad, Lewin Nancy E, Choi Sung-Hee, Blumberg Peter M, Kazanietz Marcelo G

Abstract excerpt

Recent studies established that the Rac-GAP beta2-chimaerin plays important roles in development, neuritogenesis, and cancer progression. A unique feature of beta2-chimaerin is that it can be activated by phorbol esters and the lipid second messenger diacylglycerol (DAG), which bind with high aff...

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Identifiers

PMID: 19618918
DOI: 10.1021/bi9010623
PMCID: PMC2756504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19618918-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.PMID 19618918Read ↗

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