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Article

Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.

Biochemistry - 1 Sept 2009

Sosa Maria Soledad, Lewin Nancy E, Choi Sung-Hee, Blumberg Peter M, Kazanietz Marcelo G

Abstract excerpt

Recent studies established that the Rac-GAP beta2-chimaerin plays important roles in development, neuritogenesis, and cancer progression. A unique feature of beta2-chimaerin is that it can be activated by phorbol esters and the lipid second messenger diacylglycerol (DAG), which bind with high affinity to its C1 domain and promote beta2-chimaerin translocation to membranes, leading to the inactivation of the small...

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Identifiers

PMID: 19618918
DOI: 10.1021/bi9010623
PMCID: PMC2756504

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Source receipt: pubmed, retrieved 7 Sept 2026.

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