Article
Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 2006
Chen JianFeng, Yang Wei, Kim Minsoo, Carman Christopher V, Springer Timothy A
Abstract excerpt
The adhesiveness of integrin alpha(L)beta(2) is modulated by divalent cations. We mutated three metal ion-binding sites in the beta(2) I domain. The metal ion-dependent adhesion site (MIDAS) and the ligand-induced metal-binding site are required for ligand binding and sufficient for synergism between Ca(2+) and Mg(2+). Adjacent to MIDAS (ADMIDAS) mutants are constitutively active but remain bent, with poor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.