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Article

Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry.

Molecular & cellular proteomics : MCP - 1 Jul 2005

Roth Michael J, Forbes Andrew J, Boyne Michael T, Kim Yong-Bin, Robinson Dana E, Kelleher Neil L

Abstract excerpt

The human proteome is a highly complex extension of the genome wherein a single gene often produces distinct protein forms due to alternative splicing, RNA editing, polymorphisms, and posttranslational modifications. Such biological variation compounded by the high sequence identity within gene families currently overwhelms the complete and routine characterization of mammalian proteins by MS. A new data base of...

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Identifiers

PMID: 15863400
DOI: 10.1074/mcp.M500064-MCP200
PMCID: PMC1307493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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