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Article

"Proteotyping": population proteomics of human leukocytes using top down mass spectrometry.

Analytical chemistry - 15 Apr 2008

Roth Michael J, Parks Bryan A, Ferguson Jonathan T, Boyne Michael T, Kelleher Neil L

Abstract excerpt

Characterizing combinations of coding polymorphisms (cSNPs), alternative splicing and post-translational modifications (PTMs) on a single protein by standard peptide-based proteomics is challenging owing to <100% sequence coverage and the uncoupling effect of proteolysis on such variations >10-20 residues apart. Because top down MS measures the whole protein, combinations of all the variations affecting primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18351787
DOI: 10.1021/ac800141g
PMCID: PMC2615201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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