Article
How many human proteoforms are there?
Nature chemical biology - 14 Feb 2018
Aebersold Ruedi, Agar Jeffrey N, Amster I Jonathan, Baker Mark S, Bertozzi Carolyn R, Boja Emily S, Costello Catherine E, Cravatt Benjamin F, Fenselau Catherine, Garcia Benjamin A, Ge Ying, Gunawardena Jeremy, Hendrickson Ronald C, Hergenrother Paul J, Huber Christian G, Ivanov Alexander R, Jensen Ole N, Jewett Michael C, Kelleher Neil L, Kiessling Laura L, Krogan Nevan J, Larsen Martin R, Loo Joseph A, Ogorzalek Loo Rachel R, Lundberg Emma, MacCoss Michael J, Mallick Parag, Mootha Vamsi K, Mrksich Milan, Muir Tom W, Patrie Steven M, Pesavento James J, Pitteri Sharon J, Rodriguez Henry, Saghatelian Alan, Sandoval Wendy, Schlüter Hartmut, Sechi Salvatore, Slavoff Sarah A, Smith Lloyd M, Snyder Michael P, Thomas Paul M, Uhlén Mathias, Van Eyk Jennifer E, Vidal Marc, Walt David R, White Forest M, Williams Evan R, Wohlschlager Therese, Wysocki Vicki H, Yates Nathan A, Young Nicolas L, Zhang Bing
Abstract excerpt
Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA- and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and...
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