Article
The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans.
Development (Cambridge, England) - 1 Jun 2010
Flowers Eileen B, Poole Richard J, Tursun Baris, Bashllari Enkelejda, Pe'er Itsik, Hobert Oliver
Abstract excerpt
Transcriptional co-repressors of the Groucho/TLE family are important regulators of development in many species. A subset of Groucho/TLE family members that lack the C-terminal WD40 domains have been proposed to act as dominant-negative regulators of Groucho/TLE proteins, yet such a role has not been conclusively proven. Through a mutant screen for genes controlling a left/right asymmetric cell fate decision in...
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