Article
Expression of interleukin-10 splicing variants is a positive prognostic feature in relapsed childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2005
Wu Shuling, Gessner Reinhard, Taube Tillmann, von Stackelberg Arend, Henze Günter, Seeger Karl
Abstract excerpt
PURPOSE: Biologic features of hematologic malignancies have prognostic implications and are essential elements in the design of current therapeutic trials. This study aimed to determine the expression of a splicing-derived variant of interleukin (IL) -10 in leukemic cells and its clinical relevance in children with acute lymphoblastic leukemia (ALL) at first relapse. PATIENTS AND METHODS: Between January 1997 and...
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