Article
Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2006
Attarbaschi Andishe, Mann Georg, König Margit, Steiner Manuel, Strehl Sabine, Schreiberhuber Anita, Schneider Björn, Meyer Claus, Marschalek Rolf, Borkhardt Arndt, Pickl Winfried F, Lion Thomas, Gadner Helmut, Haas Oskar A, Dworzak Michael N
Abstract excerpt
PURPOSE: Mixed lineage leukemia (MLL) abnormalities occur in approximately 50% of childhood pro-B acute lymphoblastic leukemia (ALL). However, the incidence and type of MLL rearrangements have not been determined in common ALL (cALL) and CD10+ or CD10- pre-B ALL. EXPERIMENTAL DESIGN: To address this question, we analyzed 29 patients with pro-B ALL, 11 patients with CD10- pre-B ALL, 23 pre-B, and 26 cALL patients...
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