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Article

Does a central MHC gene in linkage disequilibrium with HLA-DRB1*0401 affect susceptibility to type 1 diabetes?

Genes and immunity - 1 Jun 2005

Windsor L, Puschendorf M, Allcock R, Scott A, Sayer D, Kucharzak R, Gut I, McCann V, Davis E, Witt C, Christiansen F, Price P

Abstract excerpt

Subtypes of HLA-DR4 are associated with susceptibility or protection against type 1 diabetes (T1DM). We addressed whether this reflects linkage disequilibrium with the true susceptibility locus by studying broader MHC haplotypes marked by alleles of HLA-B, IKBL (adjacent to TNFA) and complement C4. The study used a largely Caucasian cohort from Western Australia. HLA-DRB1*0401 and HLA-DRB1*0405 marked...

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Identifiers

PMID: 15858601
DOI: 10.1038/sj.gene.6364210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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