Article
Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM.
Immunogenetics - 1 Jan 1992
Degli-Esposti M A, Abraham L J, McCann V, Spies T, Christiansen F T, Dawkins R L
Abstract excerpt
The major histocompatibility complex (MHC) contains multiple and diverse genes which may be relevant to the induction and regulation of autoimmune responses in insulin dependent diabetes mellitus (IDDM). In addition to HLA class I and II, the possible candidates include TNF, C4, and several other poorly defined polymorphic genes in the central MHC region. This study describes two approaches which take advantage...
Topics
- Adult
- Alleles
- Cell Line, Transformed
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- HLA Antigens
- HLA-B Antigens
- HLA-DR3 Antigen
- Haplotypes
- Humans
- Major Histocompatibility Complex