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Article

Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM.

Immunogenetics - 1 Jan 1992

Degli-Esposti M A, Abraham L J, McCann V, Spies T, Christiansen F T, Dawkins R L

Abstract excerpt

The major histocompatibility complex (MHC) contains multiple and diverse genes which may be relevant to the induction and regulation of autoimmune responses in insulin dependent diabetes mellitus (IDDM). In addition to HLA class I and II, the possible candidates include TNF, C4, and several other poorly defined polymorphic genes in the central MHC region. This study describes two approaches which take advantage...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1356098
DOI: 10.1007/BF00218041

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM.PMID 1356098Read ↗

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The HLA 8.1 ancestral haplotype is strongly linked to the C allele of -429T>C promoter polymorphism of receptor of the advanced glycation endproduct (RAGE) gene. Haplotype-independent association of the -429C allele with high hemoglobinA1C levels in diabetic patients.Semantic proximity Read ↗

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