Article
Can MHC class II genes mediate resistance to type 1 diabetes?
Immunology and cell biology - 1 Dec 2001
Price P, Cheong K Y, Boodhoo A, Witt C S, McCann V, Christiansen F T, Allcock R J
Abstract excerpt
Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed from studies of transgenic mice, usually using the diabetes-prone non-obese diabetic (NOD) strain....
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