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Article

A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression.

Oncogene - 4 Aug 2005

Mercer Kathryn, Giblett Susan, Oakden Anthony, Brown Jane, Marais Richard, Pritchard Catrin

Abstract excerpt

The Raf/MEK/ERK (extracellular regulated kinase) signal transduction pathway controls the ability of cells to respond to proliferative, apoptotic, migratory and differentiation signals. We have investigated the combined contribution of A-Raf and Raf-1 isotypes to signalling through this pathway by generating mice with knockout mutations of both A-raf and raf-1 genes. Double knockout (DKO) mice have a more severe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15856007
DOI: 10.1038/sj.onc.1208707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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