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Article

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.

Mechanisms of development - 1 Mar 2000

Wojnowski L, Stancato L F, Larner A C, Rapp U R, Zimmer A

Abstract excerpt

The three mammalian Raf serine/threonine protein kinases mediate the transduction of proliferative and differentiative signals from cell surface receptors to the nucleus. In vertebrates, Raf signaling has been implicated in the progression of mouse embryos through the two-cell stage and in the induction of posterior mesoderm. However, mouse embryos mutant for each of the Raf genes exhibit no developmental defects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10704835
DOI: 10.1016/s0925-4773(99)00276-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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