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Article

Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 May 2005

Smith Anthony M, Feldman Charles, Massidda Orietta, McCarthy Kerrigan, Ndiweni Dalu, Klugman Keith P

Abstract excerpt

We report the unusual involvement of altered PBP 2A in the development of beta-lactam resistance in Streptococcus pneumoniae. This was investigated amid three identical serotype 14 isolates (designated isolates 1, 2, and 3, respectively) of pneumococci cultured successfully from the blood of a human immunodeficiency virus-seropositive child with recurrent pneumonia. The passage of this strain through its human...

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Identifiers

PMID: 15855525
DOI: 10.1128/AAC.49.5.2002-2007.2005
PMCID: PMC1087663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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