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Article

Pneumococcal beta-lactam resistance due to a conformational change in penicillin-binding protein 2x.

The Journal of biological chemistry - 20 Jan 2006

Carapito Raphaël, Chesnel Laurent, Vernet Thierry, Zapun André

Abstract excerpt

Streptococcus pneumoniae is a life-threatening human pathogen that is increasingly resistant to a wide array of drugs. Resistance to beta-lactams, the most widely used antibiotics, is correlated with tens of amino acid substitutions in their targets; that is, the penicillin-binding proteins (PBPs), resulting from multiple events of recombination. To discriminate relevant substitutions from those that are...

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Identifiers

PMID: 16303769
DOI: 10.1074/jbc.M511506200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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