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Identical Penicillin-Binding Domains in Penicillin-Binding Proteins of <i>Streptococcus pneumoniae</i> Clinical Isolates with Different Levels of β-Lactam Resistance

25 Jun 2005

Abstract excerpt

We have sequenced the penicillin-binding domains of the complete repertoire of penicillin-binding proteins and MurM from 22 clinical isolates of Streptococcus pneumoniae that span a wide range of beta-lactam resistance levels. Evidence of mosaicism was found in the genes encoding PBP 1a, PBP 2b, PBP 2x, MurM, and, possibly, PBP 2a. Five isolates were found to have identical PBP and MurM sequences, even though the...

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PMID: 15980366
DOI: 10.1128/aac.49.7.2895-2902.2005

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