Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread.

doi:10.1128/JCM.01993-19

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Article

Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread.

Journal of clinical microbiology - 25 Mar 2020

Musser James M, Beres Stephen B, Zhu Luchang, Olsen Randall J, Vuopio Jaana, Hyyryläinen Hanne-Leena, Gröndahl-Yli-Hannuksela Kirsi, Kristinsson Karl G, Darenberg Jessica, Henriques-Normark Birgitta, Hoffmann Steen, Caugant Dominque A, Smith Andrew J, Lindsay Diane S J, Boragine David M, Palzkill Timothy

Abstract excerpt

Recently, two related Streptococcus pyogenes strains with reduced susceptibility to ampicillin, amoxicillin, and cefotaxime, antibiotics commonly used to treat S. pyogenes infections, were reported. The two strains had the same nonsynonymous (amino acid-substituting) mutation in the pbp2x gene, encoding penicillin-binding protein 2X (PBP2X). This concerning report led us to investigate our library of 7,025 genome...

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PMID: 31996443
DOI: 10.1128/JCM.01993-19
PMCID: PMC7098749

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