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Article

Dok-1 and Dok-2 are negative regulators of T cell receptor signaling.

International immunology - 1 Apr 2007

Yasuda Tomoharu, Bundo Kenji, Hino Ayako, Honda Kazuho, Inoue Akane, Shirakata Masaki, Osawa Mitsujiro, Tamura Toshiki, Nariuchi Hideo, Oda Hideaki, Yamamoto Tadashi, Yamanashi Yuji

Abstract excerpt

Interaction of the TCR complex with self- or foreign peptides is a central event in the immune responses. Upon TCR stimulation, a protein-tyrosine kinase (PTK), ZAP-70, is recruited to signaling units of the TCR complex, such as TCRzeta, to play an essential role in T cell activation. Here, we find that mice lacking adaptor proteins Dok-1 and Dok-2 show augmented responses to thymus-dependent, but not...

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Identifiers

PMID: 17329234
DOI: 10.1093/intimm/dxm015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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