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Article

Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor.

Journal of molecular biology - 29 Oct 2004

Zhang Yong, Yan Zhiyong, Farooq Amjad, Liu Xiujie, Lu Changlin, Zhou Ming-Ming, He Cheng

Abstract excerpt

Phosphotyrosine binding (PTB) domains of the adaptor proteins Doks (downstream of tyrosine kinases) play an important role in regulating signal transduction of cell-surface receptors in cell growth, proliferation and differentiation; however, ligand specificity of the Dok PTB domains has until now remained elusive. In this study, we have investigated the molecular basis of specific association between the Dok1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15476828
DOI: 10.1016/j.jmb.2004.08.072

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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