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Article

KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun.

Free radical biology & medicine - 1 Mar 2014

Goitre Luca, De Luca Elisa, Braggion Stefano, Trapani Eliana, Guglielmotto Michela, Biasi Fiorella, Forni Marco, Moglia Andrea, Trabalzini Lorenza, Retta Saverio Francesco

Abstract excerpt

Loss-of-function mutations in the KRIT1 gene (CCM1) have been associated with the pathogenesis of cerebral cavernous malformations (CCM), a major cerebrovascular disease. However, KRIT1 functions and CCM pathogenetic mechanisms remain incompletely understood. Indeed, recent experiments in animal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24291398
DOI: 10.1016/j.freeradbiomed.2013.11.020
PMCID: PMC3994518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24291398-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun.PMID 24291398Read ↗

KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen SpeciesSemantic proximity Read ↗

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