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Article

CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis.

Experimental cell research - 10 Mar 2005

Narita Tadashi, Nishimura Tadahiro, Yoshizaki Kazuyuki, Taniyama Tadayoshi

Abstract excerpt

CIN85 is a multidomain protein that associates with receptors carrying tyrosine kinase domains. Here we report that it is also a component of the signaling complex associated with tumor necrosis factor receptor 1 (TNFR1), which lacks a tyrosine kinase domain. This was established by showing that CIN85 was co-precipitated with TNFR1, TRADD, cIAP-1 and TARF1/2, but not with FADD, RIP, caspase-8 or TRAF6. However,...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Tumor Necrosis Factor, Type I

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Source

Identifiers

PMID: 15707590
DOI: 10.1016/j.yexcr.2004.11.005

Genes

TNF
FADD
TRADD
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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