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Article

Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.

Molecular and cellular biology - 1 Apr 2006

Zhao Mingming, Janas Justyna A, Niki Masaru, Pandolfi Pier Paolo, Van Aelst Linda

Abstract excerpt

The Dok adaptor proteins play key regulatory roles in receptor and non-receptor kinase-initiated signaling pathways. Dok-1, the prototype member of this family, negatively regulates cell proliferation elicited by numerous growth factors, including platelet-derived growth factor (PDGF). However, how Dok-1 exerts its negative effect on mitogenesis has remained elusive. Using Dok-1 knockout cells and Dok-1 mutants...

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Identifiers

PMID: 16537894
DOI: 10.1128/MCB.26.7.2479-2489.2006
PMCID: PMC1430334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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