Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer.

EBioMedicine - 1 Jun 2016

Friedrich Teresa, Söhn Michaela, Gutting Tobias, Janssen Klaus-Peter, Behrens Hans-Michael, Röcken Christoph, Ebert Matthias P A, Burgermeister Elke

Abstract excerpt

Full-length (FL) docking protein-1 (DOK1) is an adapter protein which inhibits growth factor and immune response pathways in normal tissues, but is frequently lost in human cancers. Small DOK1 variants remain in cells of solid tumors and leukemias, albeit, their functions are elusive. To assess the so far unknown role of DOK1 in colorectal cancer (CRC), we generated DOK1 mutants which mimic the domain structure...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Intracellular Space
Share to Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoproteins

Share to PPAR gamma

Share to Protein Interaction Domains and Motifs

Share to Proto-Oncogene Proteins c-fos

Share to RNA-Binding Proteins

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 27428427
DOI: 10.1016/j.ebiom.2016.05.003
PMCID: PMC4919572

Genes

DOK1
FOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer.PMID 27428427Read ↗

Comprehensive analysis of Downstream of Kinase (DOK) Genes in Pan-cancerSemantic proximity Read ↗

Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer.Semantic proximity Read ↗

Identification of DOK genes as lung tumor suppressors.Semantic proximity Read ↗

Loss of DOK2 induces carboplatin resistance in ovarian cancer via suppression of apoptosisSemantic proximity Read ↗

Identification of Dok-4b, a Dok-4 splice variant with enhanced inhibitory properties.Semantic proximity Read ↗

Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.Semantic proximity Read ↗

Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.Semantic proximity Read ↗

Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor.Semantic proximity Read ↗

DOK2 inhibits EGFR-mutated lung adenocarcinoma.Semantic proximity Read ↗

A nuclear export signal and phosphorylation regulate Dok1 subcellular localization and functions.Semantic proximity Read ↗

Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial–mesenchymal transition and colorectal cancer aggressivenessSemantic proximity Read ↗

Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.