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Article

A prognostic signature of defective p53‐dependent G1 checkpoint function in melanoma cell lines

27 Apr 2012

Abstract excerpt

Melanoma cell lines and normal human melanocytes (NHM) were assayed for p53-dependent G1 checkpoint response to ionizing radiation (IR)-induced DNA damage. Sixty-six percent of melanoma cell lines displayed a defective G1 checkpoint. Checkpoint function was correlated with sensitivity to IR with checkpoint-defective lines being radio-resistant. Microarray analysis identified 316 probes whose expression was...

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PMID: 22540896
DOI: 10.1111/j.1755-148x.2012.01010.x

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