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Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria

26 Jul 2024

Abstract excerpt

The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically Salmonella Typhimurium (Stm) and Mycobacterium tuberculosis (Mtb). We screened 827 ATP-competitive kinase inhibitors with known target profiles from two Published...

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PMID: 39060313
DOI: 10.1038/s41598-024-68102-6

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