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Aminoglycoside phosphotransferases: proteins, structure, and mechanism

1 Jan 1999

Abstract excerpt

Aminoglycoside antibiotics constitute an important class of clinically useful drugs which are imperiled by the emergence of resistant organisms. Aminoglycoside resistance in the clinics is primarily due to the presence of modifying enzymes which N-acetylate, O-adenylate or O-phosphorylate the antibiotics. The latter family of enzymes are termed the aminoglycoside phosphotransferases or kinases and are the subject...

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PMID: 9872733
DOI: 10.2741/wright

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