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Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila

21 Jan 2010

Abstract excerpt

Aminoglycoside phosphotransferases (APHs) constitute a diverse group of enzymes that are often the underlying cause of aminoglycoside resistance in the clinical setting. Several APHs have been extensively characterized, including the elucidation of the three-dimensional structure of two APH(3') isozymes and an APH(2'') enzyme. Although many APHs are plasmid-encoded and are capable of inactivating numerous...

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PMID: 20089863
DOI: 10.1074/jbc.m109.038364

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