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Article

Congenital Diseases of DNA Replication: Clinical Phenotypes and Molecular Mechanisms.

International journal of molecular sciences - 18 Jan 2021

Schmit Megan, Bielinsky Anja-Katrin

Abstract excerpt

Deoxyribonucleic acid (DNA) replication can be divided into three major steps: initiation, elongation and termination. Each time a human cell divides, these steps must be reiteratively carried out. Disruption of DNA replication can lead to genomic instability, with the accumulation of point mutations or larger chromosomal anomalies such as rearrangements. While cancer is the most common class of disease...

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PMID: 33477564
DOI: 10.3390/ijms22020911
PMCID: PMC7831139

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