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Article

Chemical conditionality: a genetic strategy to probe organelle assembly.

Cell - 22 Apr 2005

Ruiz Natividad, Falcone Brian, Kahne Daniel, Silhavy Thomas J

Abstract excerpt

The assembly of the Escherichia coli outer membrane (OM) is poorly understood. Although insight into fundamental cellular processes is often obtained from studying mutants, OM-defective mutants have not been very informative because they generally have nonspecific permeability defects. Here we show that toxic small molecules can be used in selections employing strains with permeability defects to create...

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Identifiers

PMID: 15851036
DOI: 10.1016/j.cell.2005.02.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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