Article
Mutant libraries reveal negative design shielding proteins from supramolecular self-assembly and relocalization in cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2022
Garcia Seisdedos Hector, Levin Tal, Shapira Gal, Freud Saskia, Levy Emmanuel D
Abstract excerpt
Understanding the molecular consequences of mutations in proteins is essential to map genotypes to phenotypes and interpret the increasing wealth of genomic data. While mutations are known to disrupt protein structure and function, their potential to create new structures and localization phenotypes has not yet been mapped to a sequence space. To map this relationship, we employed two homo-oligomeric protein...
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