Article
Amplification of RNAi--targeting HLA mRNAs.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2005
Gonzalez Sergio, Castanotto Daniela, Li Haitang, Olivares Simon, Jensen Michael C, Forman Stephen J, Rossi John J, Cooper Laurence J N
Abstract excerpt
Posttranscriptional suppression of gene expression can be achieved by introduction of sequence-specific small interfering (si) RNA duplexes and by de novo intracellular synthesis of short sequence-specific double-stranded RNAs. However, achieving desired levels of knockdown is a barrier to successful analytic and therapeutic application. We demonstrate that increasing expression of introduced short hairpin RNA...
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