Article
Splice-Switching Antisense Oligonucleotides as a Targeted Intrinsic Engineering Tool for Generating Armored Redirected T Cells.
Nucleic acid therapeutics - 1 Apr 2021
Ceccarello Erica, Tabaglio Tommaso, Koh Sarene, Oei Vincent, Teo Winnie, Jonathan Owen Julianto, Pavesi Andrea, Chen Qingfeng, Bertoletti Antonio, Wee Keng Boon, Guccione Ernesto
Abstract excerpt
Modification of specificity of T cells for the use in adoptive transfer (CAR- or TCR-redirected T cells) has revolutionized the therapy of liquid tumors and some infectious diseases. However, several obstacles are still hampering the efficacy of such potent therapy, hence concurrent modification of the function is also required to obtain successful results. Here we show the use of splice-switching antisense...
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