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Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells.

Biochemical and biophysical research communications - 3 Jun 2005

Zacal Natalie, Espiritu Myrna, Singh Gurmit, Rainbow Andrew J

Abstract excerpt

We have reported previously the isolation of three photodynamic therapy (PDT)-resistant human colon carcinoma HT29 cell lines that show increased expression of the Hsp27 and BNip3 protein and a decreased expression of the mutant p53 protein compared to parental HT29 cells. Since mutant p53 and increased expression of Hsp27 have been associated with resistance to various chemotherapeutic agents, whereas BNip3 is a...

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PMID: 15850808
DOI: 10.1016/j.bbrc.2005.03.213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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