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Article

Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.

Molecular cancer therapeutics - 1 Jul 2005

Bauer Joshua A, Trask Douglas K, Kumar Bhavna, Los Gerrit, Castro Jason, Lee Julia Shin-Jung, Chen Jianyong, Wang Shaomeng, Bradford Carol R, Carey Thomas E

Abstract excerpt

Organ preservation protocols in head and neck squamous cell carcinoma (HNSCC) are limited by tumors that fail to respond. We observed that larynx preservation and response to chemotherapy is significantly associated with p53 overexpression, and that most HNSCC cell lines with mutant p53 are more sensitive to cisplatin than those with wild-type p53. To investigate cisplatin resistance, we studied two HNSCC cell...

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Identifiers

PMID: 16020667
DOI: 10.1158/1535-7163.MCT-05-0081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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