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Up-regulation of Hsp27 Plays a Role in the Resistance of Human Colon Carcinoma HT29 Cells to Photooxidative Stress¶

1 Jan 2002

Abstract excerpt

The Photofrin-resistant cell line (HT29-P14) was used in the present study to investigate the mechanism(s) involved in Photofrin-mediated photodynamic therapy (PDT). We compared gene expression profiles between the resistant cell line and its parental cell line (HT29) using DNA microarray analysis. A significant up-regulation of small heat shock protein 27 (Hsp27) was found in HT29-P14 cells. The elevated Hsp27...

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PMID: 12126313
DOI: 10.1562/0031-8655(2002)0760098urohpa2.0.co2

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