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Article

Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells

1 Apr 2003

Abstract excerpt

BBR3464 is a trinuclear platinum complex that exhibits a potent cytotoxicity and efficacy against cisplatin-resistant tumors. To better understand the determinants of cellular resistance to BBR3464, we selected a resistant ovarian carcinoma cell line after exposure to the complex. The resistant cells (A2780/BBR3464) exhibited a high level of resistance to the selecting agent, but a marginal cross-resistance to...

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PMID: 12740909
DOI: 10.1002/ijc.11140

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