Frontal and limbic metabolic differences in subjects selected according to genetic variation of the SLC6A4 gene polymorphism.

doi:10.1016/j.neuroimage.2004.12.020

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Frontal and limbic metabolic differences in subjects selected according to genetic variation of the SLC6A4 gene polymorphism.

NeuroImage - 1 May 2005

Graff-Guerrero A, De la Fuente-Sandoval C, Camarena B, Gómez-Martin D, Apiquián R, Fresán A, Aguilar A, Méndez-Núñez J C, Escalona-Huerta C, Drucker-Colín R, Nicolini H

Abstract excerpt

Allelic variants in the promoter region of the serotonin transporter (5-HTT) gene have been implicated in several psychiatric disorders and personality traits. In particular, two common alleles in a variable repeat sequence of the promoter region (SLC6A4) have been differentially associated with a display of abnormal levels of anxiety and affective illness in individuals carrying the "s" allele. The aim of this...

Topics

Adult
Alleles
Brain Mapping
Female
Frontal Lobe
Genotype
Humans
Image Processing, Computer-Assisted
Limbic System
Male
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Transport Proteins

Middle Aged

Nerve Tissue Proteins

Polymorphism, Genetic

Positron-Emission Tomography

Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed

Identifiers

PMID: 15850737
DOI: 10.1016/j.neuroimage.2004.12.020

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frontal and limbic metabolic differences in subjects selected according to genetic variation of the SLC6A4 gene polymorphism.PMID 15850737Read ↗

Genetic variation in serotonin transporter alters resting brain function in healthy individuals.Semantic proximity Read ↗

The serotonin transporter genotype is associated with intermediate brain phenotypes that depend on the context of eliciting stressor.Semantic proximity Read ↗

Serotonin transporter polymorphism modulates N-back task performance and fMRI BOLD signal intensity in healthy women.Semantic proximity Read ↗

Effects of serotonin transporter promoter polymorphisms on serotonin function.Semantic proximity Read ↗

Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR.Semantic proximity Read ↗

The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia.Semantic proximity Read ↗

Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression.Semantic proximity Read ↗

Effect of 5-HTTLPR on current source density, connectivity, and topological properties of resting state EEG networks.Semantic proximity Read ↗

Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression.Semantic proximity Read ↗

Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion.Semantic proximity Read ↗

Baseline brain perfusion and the serotonin transporter promoter polymorphism.Semantic proximity Read ↗

Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.