The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia.

doi:10.1016/j.nicl.2015.07.017

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Article

The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia.

NeuroImage. Clinical - 1 Jan 2015

Yokoyama Jennifer S, Bonham Luke W, Sturm Virginia E, Adhimoolam Babu, Karydas Anna, Coppola Giovanni, Miller Bruce L, Rankin Katherine P

Abstract excerpt

The serotonin transporter length polymorphism (5-HTTLPR) short allele (5-HTTLPR-s) has been associated with differential susceptibility for anxiety and depression in multiple psychiatric disorders. 5-HTTLPR-s modifies the serotonergic systems that support emotion and behavioral regulation by reducing gene expression, which slows the reuptake of serotonin, and is associated with distinct morphological and...

Topics

Aged
Aged, 80 and over
Female
Frontotemporal Dementia
Gene Frequency
Genetic Variation
Genotype
Gray Matter
Humans
Image Processing, Computer-Assisted

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Male

Middle Aged

Mood Disorders

Psychiatric Status Rating Scales

Serotonin Plasma Membrane Transport Proteins

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Identifiers

PMID: 26509115
DOI: 10.1016/j.nicl.2015.07.017
PMCID: PMC4576414

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