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Article

The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia.

NeuroImage. Clinical - 1 Jan 2015

Yokoyama Jennifer S, Bonham Luke W, Sturm Virginia E, Adhimoolam Babu, Karydas Anna, Coppola Giovanni, Miller Bruce L, Rankin Katherine P

Abstract excerpt

The serotonin transporter length polymorphism (5-HTTLPR) short allele (5-HTTLPR-s) has been associated with differential susceptibility for anxiety and depression in multiple psychiatric disorders. 5-HTTLPR-s modifies the serotonergic systems that support emotion and behavioral regulation by reducing gene expression, which slows the reuptake of serotonin, and is associated with distinct morphological and...

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Identifiers

PMID: 26509115
DOI: 10.1016/j.nicl.2015.07.017
PMCID: PMC4576414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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