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Article

Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression.

Journal of psychiatric research - 1 Apr 2011

Brockmann Holger, Zobel Astrid, Schuhmacher Anna, Daamen Marcel, Joe Alexius, Biermann Kim, Schwab Sibylle G, Biersack Hans-Juergen, Maier Wolfgang, Boecker Henning

Abstract excerpt

Neuroimaging studies in major depressive disorder (MDD) have indicated dysregulation in a network involving prefrontal cortex, subgenual cingulate and the amygdalae, which is known to be modulated by serotonin. The serotonergic system is the principal target for pharmacological treatment in MDD and the functional variable serotonin promoter polymorphism (5-HTTLPR) influences susceptibility, course and treatment...

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Identifiers

PMID: 20934189
DOI: 10.1016/j.jpsychires.2010.08.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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