Article
Sensitivity of NMR residual dipolar couplings to perturbations in folded and denatured staphylococcal nuclease.
Biochemistry - 3 May 2005
Sallum Christine O, Martel David M, Fournier Robert S, Matousek William M, Alexandrescu Andrei T
Abstract excerpt
The invariance of NMR residual dipolar couplings (RDCs) in denatured forms of staphylococcal nuclease to changes in denaturant concentration or amino acid sequence has previously been attributed to the robustness of long-range structure in the denatured state. Here we compare RDCs of the wild-type nuclease with those of a fragment that retains a folded OB-fold subdomain structure despite missing the last 47 of...
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