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Article

Coupling between local structure and global stability of a protein: mutants of staphylococcal nuclease.

Biochemistry - 15 May 1990

Alexandrescu A T, Hinck A P, Markley J L

Abstract excerpt

Staphylococcal nuclease exists in solution as a mixture of two folded (N and N') and two unfolded (U and U*) forms. Earlier workers [Evans et al. (1989) Biochemistry 28, 362] have proposed that the N'/N and U/U* structural differences involve cis/trans isomerization about the Lys116-Pro117 peptide bond with N and U cis and N' and U* trans. The present results show that residue changes throughout the nuclease...

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Identifiers

PMID: 2372535
DOI: 10.1021/bi00471a003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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