Article
Coupling between local structure and global stability of a protein: mutants of staphylococcal nuclease.
Biochemistry - 15 May 1990
Alexandrescu A T, Hinck A P, Markley J L
Abstract excerpt
Staphylococcal nuclease exists in solution as a mixture of two folded (N and N') and two unfolded (U and U*) forms. Earlier workers [Evans et al. (1989) Biochemistry 28, 362] have proposed that the N'/N and U/U* structural differences involve cis/trans isomerization about the Lys116-Pro117 peptid...
Topics
- Amino Acid Sequence
- Kinetics
- Magnetic Resonance Spectroscopy
- Micrococcal Nuclease
- Molecular Structure
- Mutation
- Protein Conformation
- Stereoisomerism
- Thermodynamics