Article
Targeting intracellular calcium cycling in catecholaminergic polymorphic ventricular tachycardia: a theoretical investigation.
American journal of physiology. Heart and circulatory physiology - 1 Oct 2011
Sung Ruey J, Lo Chu-Pin, Hsiao Pi Yin, Tien Hui-Chun
Abstract excerpt
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant arrhythmogenic disorder linked to mutations in the cardiac ryanodine receptor (RyR2) and calsequestrin, predisposing the young to syncope and cardiac arrest. To define the role of β-adrenergic stimulation (BAS) and to ide...
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