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Article

In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2007

Vecchietti Stefania, Grandi Eleonora, Severi Stefano, Rivolta Ilaria, Napolitano Carlo, Priori Silvia G, Cavalcanti Silvio

Abstract excerpt

The effects of two SCN5A mutations (Y1795C, Y1795H), previously identified in one Long QT syndrome type 3 (LQT3) and one Brugada syndrome (BrS) families, were investigated by means of numerical modeling of ventricular action potential (AP). A Markov model capable of reproducing a wild-type as well as a mutant sodium current (I(Na)) was identified and was included into the Luo-Rudy ventricular cell model for...

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PMID: 16980337
DOI: 10.1152/ajpheart.00270.2006

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