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Article

ATM activation in normal human tissues and testicular cancer.

Cell cycle (Georgetown, Tex.) - 1 Jun 2005

Bartkova Jirina, Bakkenist Christopher J, Rajpert-De Meyts Ewa, Skakkebaek Niels E, Sehested Maxwell, Lukas Jiri, Kastan Michael B, Bartek Jiri

Abstract excerpt

The ATM kinase is a tumor suppressor and key regulator of biological responses to DNA damage. Cultured cells respond to genotoxic insults that induce DNA double-strand breaks by prompt activation of ATM through its autophosphorylation on serine 1981. However, whether ATM-S1981 becomes phosphorylated in vivo, for example during physiological processes that generate DSBs, is unknown. Here we produced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15846060
DOI: 10.4161/cc.4.6.1742

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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