Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy.

International journal of andrology - 1 Aug 2007

Bartkova J, Rajpert-De Meyts E, Skakkebaek N E, Lukas J, Bartek J

Abstract excerpt

DNA damage response (DDR) is emerging as a physiological anti-cancer barrier in early stages of cancer development, as shown for several types of solid cancers derived from somatic cells. Here we discuss our recently published and unpublished results on the exceptional paucity of such constitutive activation of the DDR machinery in human testicular germ cell tumours (TGCTs), including their common pre-invasive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma in Situ
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Neoplasm Invasiveness

Share to Neoplasms, Germ Cell and Embryonal

Share to Reference Values

Share to Testicular Neoplasms

Share to Testis

Source

Identifiers

PMID: 17573848
DOI: 10.1111/j.1365-2605.2007.00772.x

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy.PMID 17573848Read ↗

ATM activation in normal human tissues and testicular cancer.Semantic proximity Read ↗

Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell TumorsSemantic proximity Read ↗

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.Semantic proximity Read ↗

Developmental model for the pathogenesis of testicular carcinoma <i>in situ</i> : genetic and environmental aspectsSemantic proximity Read ↗

Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overviewSemantic proximity Read ↗

Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis.Semantic proximity Read ↗

Deregulation of the G1/S‐phase control in human testicular germ cell tumoursSemantic proximity Read ↗

Genomic instability in patients with sex determination defects and germ cell cancerSemantic proximity Read ↗

The Epigenetics of Testicular Germ Cell Tumors: Looking for Novel Disease BiomarkersSemantic proximity Read ↗

Chromosomes and Expression in Human Testicular Germ‐Cell TumorsSemantic proximity Read ↗

Recent developments in testicular germ cell tumor researchSemantic proximity Read ↗

Seminoma and Embryonal Carcinoma Footprints Identified by Analysis of Integrated Genome-Wide Epigenetic and Expression Profiles of Germ Cell Cancer Cell LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.