Article
No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2005
Kinoshita Y, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Yoneda H, Iwata N, Ozaki N
Abstract excerpt
Calcineurin, one of the serine/threonine protein phosphatase, comprises more than 1% of the total protein content in brain. This evidence points towards important roles of calcineurin in neural function. Miyakawa et al. reported that forebrain-specific calcineurin knockout mice showed the behavioral abnormalities that are often observed in schizophrenia patients. Based on this evidence, they suggested that...
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