Article
Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007
Yamada Kazuo, Gerber David J, Iwayama Yoshimi, Ohnishi Tetsuo, Ohba Hisako, Toyota Tomoko, Aruga Jun, Minabe Yoshio, Tonegawa Susumu, Yoshikawa Takeo
Abstract excerpt
The calcineurin cascade is central to neuronal signal transduction, and genes in this network are intriguing candidate schizophrenia susceptibility genes. To replicate and extend our previously reported association between the PPP3CC gene, encoding the calcineurin catalytic gamma-subunit, and schizophrenia, we examined 84 SNPs from 14 calcineurin-related candidate genes for genetic association by using 124...
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