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Article

Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2003

Gerber David J, Hall Diana, Miyakawa Tsuyoshi, Demars Sandra, Gogos Joseph A, Karayiorgou Maria, Tonegawa Susumu

Abstract excerpt

Schizophrenia is a severe psychiatric disorder characterized by a complex mode of inheritance. Forebrain-specific CNB knockout mice display a spectrum of behavioral abnormalities related to altered behaviors observed in schizophrenia patients. To examine whether calcineurin dysfunction is involved in schizophrenia etiology, we undertook studies of an initial subset of calcineurin-related genes, prioritizing ones...

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Identifiers

PMID: 12851458
DOI: 10.1073/pnas.1432927100
PMCID: PMC166426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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