Article
A case-control association analysis of CABIN1 with schizophrenia in a Japanese population.
Journal of human genetics - 1 Mar 2010
Watanabe Yuichiro, Nunokawa Ayako, Kaneko Naoshi, Someya Toshiyuki
Abstract excerpt
Calcineurin (CN) is a calcium/calmodulin-dependent serine/threonine protein phosphatase and regulates neuronal structure, neurotransmission and activity-dependent gene expression. Several studies have indicated that CN signaling is likely to be involved in the pathogenesis of schizophrenia. The gene encoding CN-binding protein 1 (CABIN1) is located on 22q11.23, one of the common susceptibility loci for...
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